Module 2: Understanding Cancer Metastasis
A deep dive into the complex process of cancer metastasis, from molecular mechanisms to clinical applications and therapeutic strategies.
Molecular Mechanisms of Metastasis
Understanding the key biological processes that enable cancer spread
Interactive Pathway Overview
EMT
Loss of adhesion, gain of mobility
Invasion
Local tissue penetration
Angiogenesis
Blood vessel formation
Immune Evasion
Avoiding immune detection
Epithelial-Mesenchymal Transition (EMT)
A cellular program that allows epithelial cells to lose their adhesive properties and gain migratory and invasive capabilities.
Tumor Angiogenesis
The formation of new blood vessels from existing vasculature to supply nutrients to growing tumors.
Immune System Evasion
Mechanisms by which cancer cells avoid detection and destruction by the immune system.
Metastatic Dormancy
A state where disseminated tumor cells remain viable but non-proliferative for extended periods.
Integration and Clinical Implications
These mechanisms don't operate in isolation but work together in complex networks. Understanding their interactions is crucial for developing effective therapeutic strategies.
Each mechanism represents both a vulnerability that cancer exploits and an opportunity for therapeutic intervention. The challenge lies in targeting these processes without disrupting normal cellular functions.
Key Insight: Successful metastasis requires coordination of multiple mechanisms, suggesting that combination therapies targeting several pathways simultaneously may be more effective than single-agent approaches.