🧬Genetic Testing Labs

From VUS Crisis to Precision Diagnostics

Transform genetic testing from a bottlenecked, manual process into a high-throughput, automated pipeline. Resolve 73% more variants with 97% cost reduction while dramatically improving patient outcomes.

73%
VUS Reduction
40-60% → 15% VUS rate
12x
Faster Turnaround
2-4 weeks → 24 hours
97%
Cost Reduction
$150 → $5 per variant
20x
Throughput Increase
Cases per analyst per week

Resolve VUS with Zero-Shot Variant Interpretation

Instantly classify variants across coding and non-coding regions with calibrated confidence scores, eliminating manual review bottlenecks.

🧬 Oracle Annihilation of Uncertainty

Click "Run Demo" to see Oracle solve this problem step-by-step with discriminative AI endpoints

Variant Triaging Pipeline

CFTR:c.1521_1523delCTTPre-screen 1,000+ variants before expensive wet-lab validation
🎯

Pathogenicity Screening

/predict_variant_impact✓ Complete
Input
locus: chr7:117199644
ref: CTT
alt: del
gene: CFTR
context: cystic_fibrosis_screening
Result
deltaLikelihood:-2.89
pathogenicity:Pathogenic
confidence:0.957
consequence:frameshift_variant
clinicalSignificance:Disease-causing
ClinVar-level pathogenicity prediction (95.7% AUROC) identifies high-priority variant for wet-lab validation
🧬

Therapeutic Context Assessment

/predict_gene_essentiality
🔬

Functional Impact Validation

/predict_protein_functionality_change

Traditional vs Oracle Approach

Comparing traditional workflows with Oracle acceleration

❌ Traditional
40-60% VUS rate$150/variant
2-4 weeks turnaround$2M/year delays
Manual expert review25% reanalysis
✅ Oracle
15% VUS rate$5/variant
24-hour turnaround$200K/year
Automated classification5% reanalysis
📈 Quantified Impact
VUS reduction40-60% → 15%
Turnaround time2-4 weeks → 24 hours
Cost per variant$150 → $5
Manual review load25% → 5%

Handle Complex Loci with Long-Context Analysis

Process variants in challenging genomic regions like HLA, immunoglobulin loci, and repetitive elements with 1M-token context windows.

🧬 Oracle Annihilation of Uncertainty

Click "Run Demo" to see Oracle solve this problem step-by-step with discriminative AI endpoints

Construct Risk Assessment

BRCA1:exon11_repair_templateUse SAE features to rank construct safety and avoid failures
🎯

Repair Template Safety

/predict_variant_impact✓ Complete
Input
sequence: repair_template_sequence
targetLocus: chr17:43044295
editType: homology_directed_repair
Result
editSafety:0.94
offTargetRisk:0.02
onTargetEfficiency:0.89
unintendedConsequences:Low
Variant impact simulation predicts safe, high-efficiency repair with minimal off-target effects
🧭

Target Site Accessibility

/predict_chromatin_accessibility
✂️

Guide RNA Optimization

/predict_crispr_spacer_efficacy

Traditional vs Oracle Approach

Comparing traditional workflows with Oracle acceleration

❌ Traditional
Complex loci failures80% VUS
Short-read limitations$500K/year
Manual curation40 hours/case
✅ Oracle
Complex loci resolved25% VUS
Long-context analysis$50K/year
Automated processing2 hours/case
📈 Quantified Impact
Complex loci success20% → 75%
Processing time40 hours → 2 hours
Cost reductionbaseline → 90% savings
Analyst productivity1 case/week → 20 cases/week

Design Quality Controls with Forge Integration

Generate synthetic positive and negative controls for assay validation, ensuring robust test performance across diverse populations.

🧬 Oracle Annihilation of Uncertainty

Click "Run Demo" to see Oracle solve this problem step-by-step with discriminative AI endpoints

Predictable Guide Design

Therapeutic_gRNA_designTrade compute for design quality with predictable AUROC scaling
🧬

Target Prioritization

/predict_gene_essentiality✓ Complete
Input
candidateGenes: KRAS, MYC, BCL2
cancerContext: NSCLC
therapeuticWindow: assess
Result
krasPriority:0.94
mycPriority:0.87
bcl2Priority:0.82
optimalTarget:KRAS
selectivityIndex:11.75
Cross-species essentiality (82-99% AUROC) identifies KRAS as optimal therapeutic target with excellent selectivity
✂️

High-Efficacy Guide Design

/predict_crispr_spacer_efficacy
🧭

Delivery Optimization

/predict_chromatin_accessibility

Traditional vs Oracle Approach

Comparing traditional workflows with Oracle acceleration

❌ Traditional
Manual control design$50K/panel
6-month validation$200K
Population bias30% failure
✅ Oracle
AI-designed controls$5K/panel
2-week validation$20K
Population-aware5% failure
📈 Quantified Impact
Control design cost$50K → $5K
Validation time6 months → 2 weeks
Population coverage70% → 95%
Assay failure rate30% → 5%

Complete Lab Transformation

73%
VUS reduction
40-60% → 15% VUS rate
12x
Turnaround acceleration
2-4 weeks → 24 hours
97%
Cost reduction
$150 → $5 per variant
20x
Throughput increase
1 → 20 cases per analyst per week

Oracle transforms genetic testing from a bottlenecked, manual process into a high-throughput, automated pipeline. Labs can process 20x more cases with 97% cost reduction while dramatically improving patient outcomes through faster, more accurate results.

Case Study: BRCA1/2 Testing Revolution

See how Oracle transforms hereditary cancer testing with instant VUS resolution and population-aware analysis

Traditional BRCA Testing

High VUS Rate
45% of BRCA1/2 variants classified as VUS, leaving patients in uncertainty
Manual Expert Review
$200+ per complex variant, 3-6 weeks turnaround time
Population Bias
Limited representation in databases, especially for non-European populations

Oracle-Powered BRCA Testing

VUS Resolution
12% VUS rate with calibrated confidence scores, 73% improvement
Instant Classification
$5 per variant, 24-hour turnaround with explainable evidence
Population-Aware
Zero-shot analysis works across all populations without training bias

BRCA Testing Transformation Impact

73%
VUS Reduction
45% → 12% VUS rate
40x
Cost Reduction
$200 → $5 per variant
90x
Faster Results
3-6 weeks → 24 hours
Universal
Population Coverage
No training bias

Complete Lab Workflow Revolution

From sample intake to final report: Oracle transforms every step of the genetic testing pipeline

Traditional Lab Workflow

1. Sample Processing
2-3 days
Manual QC checks
Cost: $50
2. Sequencing & Analysis
3-5 days
Standard pipelines
Cost: $200
3. Variant Calling
1-2 days
High false positive rate
Cost: $100
4. Manual Review
1-3 weeks
40-60% VUS rate
Cost: $150/variant
5. Expert Consultation
1-2 weeks
Bottleneck resource
Cost: $300
6. Report Generation
2-3 days
Manual formatting
Cost: $75
Total: 2-6 weeks, $875+ per case

Oracle-Powered Workflow

1. Sample Processing
2-3 days
Same high-quality processing
Cost: $50
2. Sequencing & Analysis
3-5 days
Enhanced with Oracle integration
Cost: $200
3. Oracle Variant Analysis
2 hours
Zero-shot classification
Cost: $5
4. Automated Review
4 hours
15% VUS rate
Cost: $10
5. Exception Handling
1 day
Only complex cases
Cost: $50
6. Automated Reports
2 hours
Structured, explainable
Cost: $5
Total: 1 week, $320 per case

Complete Workflow Transformation

5x
Faster Processing
2-6 weeks → 1 week
63%
Cost Reduction
$875 → $320 per case
20x
Analyst Productivity
Cases per week
95%
Automation Rate
Minimal manual review

Ready to Transform Your Lab?

Join the genetic testing revolution. Reduce VUS rates, accelerate turnaround times, and improve patient outcomes with Oracle's zero-shot variant interpretation.

Explore Oracle Platform→See Biotech Transformation→

Explore CrisPRO Products for Labs

Discover how CrisPRO products power transformation across industries