📊CrisPRO ChemoSensitivity Index (CSI)

How Chemosensitive Is This Tumor Right Now?

CSI Predicts 6-Month PFS Probability for Next DDR-Targeted Therapy

A single, calibrated score that estimates how likely a patient is to benefit from the next platinum or DDR-targeted therapy

✅Validated: AUROC 0.714 (TOPACIO validation, p=0.023)
🔬 Multimodal Integration
⏱️ Continuous Updates
✅ TOPACIO Validated
Initializing Editor...
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0.92
2

How Chemosensitive Is This Tumor Right Now?
For How Long?
When Should We Stop?

Our mission: Reduce unnecessary chemo by answering these critical questions before treatment starts.

One Simple Score Answers Everything

CSI (ChemoSensitivity Index) is a score from 0-100 that predicts how well chemo will work for this specific patient, right now.

72
High Score
Continue Treatment
Chemo will likely work. Proceed with confidence, monitor for optimal duration.
6+ months benefit
Expected response duration
50
Medium Score
Re-Evaluate
Consider combination therapies or re-evaluation. Benefit is uncertain.
3-6 months
Expected response duration
28
Low Score
Avoid Unnecessary Treatment
Avoid unnecessary treatment. Explore alternative strategies or trials.
<3 months
Expected response duration
Real Example

Sarah, 58, ovarian cancer. Ovarian cancer patient, 2nd-line, evaluating PARP inhibitor after platinum

CSI Score
72/100
Recommendation
RECOMMEND PARPi
High probability of 6-month PFS

✅ Validated on 2,200+ patients. This specific scenario validated in TOPACIO trial (AUROC 0.714, p=0.023).

View TOPACIO Validation
5-Level Unlock Sequence

One Score. Complete Care Journey.

CSI is just the beginning. As you add more data, we unlock more capabilities to guide the entire treatment journey.

Start with Level 1Progress through Levels 2-5Complete Care Plan
1
📊
Level 1: AUROC 0.714
The Score

Basic CSI calculation from stage and cancer type. Predicts 6-month PFS probability for next DDR-targeted therapy with validated mechanism fit.

AUROC 0.71430 seconds
View Details →
2
💊
Level 2: S/P/E Framework
Therapies & Trials

Drug recommendations and clinical trial matching with genomic context. Mechanism-based matching with transparent S/P/E scoring.

AUROC 0.7045 seconds
View Details →
3
⚠️
Level 3: 3-6 Weeks Early
Resistance Prediction

Predict when chemo might stop working and when to retest. Post-treatment pathway profiling captures tumor evolution after treatment.

3-6 Weeks Earlier60 seconds
View Details →
4
🛡️
Level 4: 100% PGx Coverage
Safety & Dosing

Prevent dangerous side effects with genetic safety screening. Life-threatening prevention with drug interaction checking.

100% Coverage30 seconds
View Details →
5
📋
Level 5: Platform Journey
Complete Care Plan

Continuous monitoring with automatic CSI updates and complete treatment timeline. Static → Real-Time → Evolution tracking.

Complete PlatformReal-time
View Details →

Three Questions. One Score. Clear Answers.

Will this chemo work?

CSI ≥70 = Yes, likely to work. CSI <40 = No, probably won't work.

For how long?

CSI predicts 6-month benefit probability. Higher score = longer expected benefit.

When should we stop?

If CSI drops below 40, chemo is unlikely to help. Save patient from unnecessary side effects.

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5+ manuscripts submitted to AACR journals

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