CrisPRO · Intelligence stack

Engines

Seven layers from target lock through safety receipts — each engine is a live analytical surface. Pick a card to open the full workspace.

LOCK

9/9 FDA concordance

L1 · 01

Target-Lock

OPTIMIZED

Automated target vulnerability profiling using 3D structural simulation.

AUC 0.68Open

LATIFY · 8D vector

DDR
MAPK
PI3K
IO
VEGF
HER2
EFFLUX
RSS

L2 · 02

Mechanism Alignment

ACTIVE

8D vector manifold synchronization for clinical trial failure analysis.

8D VectorOpen

MBD4 · evidence matrix

CRIPhaIn In CliPatLit

Ceralasertib p=0.034

L5 · 05

Synthetic Lethality

ACTIVE

Multi-modal evidence fuser for MBD4-LOF vulnerability discovery across 7 orthogonal modalities.

d = −0.88Open

PGx gate

DPYD↓50%
DPYD↓50%
DPYDFULL DOSE
TPMT↓30-70%

100% CPIC

L6 · 06

Safety & Dosing

ACTIVE

PGx dosing guidance and IO risk-benefit gate — 100% CPIC concordance, 83.1% RRR (PREPARE), deterministic veto logic.

100% CPICOpen

Internal / audit surfaces

Receipt ledger

CRISPRPharmaIn VitroIn VivoClinical

5 PubMed anchors · calibration bar

L7 · 07

Safety

ACTIVE

Evidence ledger: 7-axis SL matrix, PubMed receipts, CRISPR vs GDSC2 concordance, calibration rigor bar.

5 PubMedOpen

Layer order: L1 Target-Lock → L2 MoA → L5 SL → L6 PGx → L7 Evidence ledger