L6: Safety & Dosing v6.2.9

System_Safe
PREPARE: 83.1% RRR · CPIC: 100%
PGx Dosing Guidance
100% CPIC CONCORDANCE
DPYD
Intermediate Metabolizer
REDUCE 50%DPYD_TOX
DPYD
Intermediate Metabolizer
REDUCE 50%DPYD_VAR2
DPYD
Normal Metabolizer
FULL DOSEDPYD_WT
TPMT
Intermediate Metabolizer
REDUCE 30-70%TPMT_ADJ
UGT1A1
Poor Metabolizer
REDUCE 20%UGT1A1_PM
CYP2C19
Poor/Intermediate
AVOID CLOPIDOGRELCYP2C19_PM
CPIC Cases / Matched10/10 — 100%
IO Risk-Benefit Gate
NCB Gate Active
Futile Toxicity Zone
Gate ResolutionDeterministic (15/15 Pass)

Cumulative Toxicity

Monitoring anthracycline and platinum dose accumulation with cross-resistance penalties.

Systemic Burden Index
42%NOMINAL
Risk-Benefit Formula
Net_Benefit =
(p_resp × Efficacy) -
(Risk_tox × Cost)