L1 ยท ENGINE

Target Lock

How Target Lock Works

L1 โ€” Target-Lock

Is this a real metastasis driver?

L2 โ€” Mechanism Fit

Are the right patients being enrolled?

Key Insight

Both layers required. Target is almost never the failure mode.

The $300M Mistake

RIGHT target, WRONG enrollment.

Two-Layer Prediction FrameworkL1 ร— L2 โ†’ Outcome
HIGHHIGHโœ… Enroll โ€” real target, right patients
HIGHLOWโŒ Trial fails โ€” target is real, enrollment is wrong$300M
LOWHIGHโŒ Trial fails โ€” wrong target
LOWLOWโŒ Full failure
The $300M Row

CEACAM5 is the second LATIFY. Both have HIGH Target-Lock (real targets) and both failed from unselected/insufficiently gated enrollment.