Overview

L1: Target Identification

Receipt-Locked

Two-Layer Prediction Framework • 9/9 Retroactive Concordance • 6 Prospective

LATIFY Chain of Custody
Production Engine Output
Responder
Score0.114
Rank#1042
Non-Responder
Score0.91
Rank#42
Delta Fit-0.1Production cosine_sim()

(CrisPRO engine: Predicted Futility 90%; Observed HR 0.90; P=0.287; receipt: latify_curl_receipts.json)

Retroactive (2023-2024)
9/9
RETSelpercatinib
0.3526
IDH1Vorasidenib
0.3525
IDH2Vorasidenib
0.3549
PIK3CAInavolisib triple
0.3533
ERBB2Zanidatamab
0.3526
KMT2ARevumenib
0.3529
FGFR3Erdafitinib
0.3527
NRG1Zenocutuzumab
0.3525
FOLR1Mirvetuximab (ELAHERE)
0.3527
Prospective (Feb 2026)
Immutable
HER3Patritumab Dx (HER3-DXd)
APPROVE
TROP2Dato-DXd
APPROVE
B7H4AZD8205
PENDING
CEACAM5Tusamitamab Ravtansine
FAILURE
KRAS G12CAdagrasib+Cetuximab
N/A
ROS1Zidesamtinib (NVL-520)
APPROVE
THE $300M ROW

CEACAM5 is the second LATIFY. Both have HIGH Target-Lock (real targets) and both failed from unselected/insufficiently gated enrollment.