Metastatic Cascade
Log
[0]L1_TARGET_STANDBY
[1]MAPPING_CASCADE_STEPS
[2]READY_FOR_INTERCEPT
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AF3 Guide
TWIST1_10
Target
TWIST1
pLDDT
67.9
iPTM
0.38
AF3 PASSTWIST1 · structure
Lock gene
TWIST1
AF3 guide
TWIST1_10
Target-Lock
—
Impact
High
Lock invasion drivers before basement membrane exit (MMP2/MMP9 axis).
Mechanism Detail
Local Invasion
EMT · ECM breach
Lock invasion drivers before basement membrane exit (MMP2/MMP9 axis).
AF3 RNA–DNA gate
pLDDT ≥5067.9
iPTM ≥0.30.38
Cohort 15/15 pass · 96nt gRNA + 60bp DNA
L1 Target-Lock ranks drivers on 38 genes × 8 steps (Evo2 + Enformer). Structural triage is pre-synthesis only — not cleavage validated.