CRISPR Intelligence: Advanced Therapeutic R&D Platform
Accelerate therapeutic R&D by replacing years of trial-and-error with weeks of precise, computational validation, creating validated therapeutic candidates with unprecedented speed and accuracy.
Our Vision
Our vision is to establish the CrisPRO Intelligence Platform as the essential system for CRISPR-based therapeutic R&D. We will transform slow, expensive, and uncertain traditional methods by providing a unified platform that moves from target identification to validated pre-clinical assets with optimal precision.
Challenge → Solution Matrix
Developing CRISPR-based therapies faces significant challenges with current tools and methodologies. Our platform addresses these critical bottlenecks:
**Translation Challenges:
Common Problem
Translation Challenges:
Significant gaps exist between successful lab experiments and viable therapeutics, with critical factors like immunogenicity and delivery often addressed late in development.
Our Solution
Decisive Outcome Analysis (CRISPResso2 on Steroids)
Achieve faster, more reliable, and significantly more insightful analysis of your CRISPR experimental results. This provides clearer, more robust data for critical milestone reporting and internal decision-making, saving time and preventing costly misinterpretations.
Technology Foundation
Core technological capabilities enabling advanced genomic insights.
The Zeta Oracle (Predictive AI): Assesses the functional impact of any edit to validate therapeutic targets before an experiment is ever run.
Core Capabilities
4 advanced AI-powered capabilities designed to transform your workflow
Our analyze_single_variant AI is integral to intelligent gRNA design by:
- Assessing Target Site Integrity: Before finalizing a gRNA, the AI analyzes the target genomic region for any known functional variants (SNPs) that could impact gRNA binding efficiency or PAM recognition, preventing failed edits due to patient or cell-line specific genetics.
- Evaluating Potential Off-Target Impact: For top off-target site predictions, the AI assesses if an unintended edit would fall on a known functionally important variant elsewhere in the genome, allowing for a more sophisticated risk assessment beyond simple sequence similarity.
- Informing gRNA Selection Near Functional Elements: The AI helps researchers understand if a potential gRNA target site overlaps with or is adjacent to known regulatory elements whose disruption by Cas9 cleavage could have unintended functional consequences.
Value for Every Team
8 benefits across 2 stakeholder groups
For Scientists & Research Labs
Design with Unprecedented Confidence: Leverage best-in-class AI to design highly potent and specific guide RNAs from the start, dramatically increasing the success rate of your editing experiments and minimizing costly validation cycles.
Go from Raw Data to Actionable Insight, Faster: Let our AI Co-Pilot handle the heavy lifting of complex NGS data analysis and therapeutic contextualization, transforming your experimental results into clear, decision-ready insights in a fraction of the time.
Democratize Advanced Computational Biology: Access a suite of sophisticated AI tools for variant effect prediction, off-target analysis, and experimental design, without needing a dedicated bioinformatics team. Focus on your science, not on building analysis pipelines.
Produce High-Impact, Publishable Results: Generate higher quality, more reproducible data with AI-guided experimental design and analysis, strengthening your publications, grant applications, and contributions to the field.
Concluding Thoughts
The CRISPR Intelligence Platform transforms therapeutic design from a manual, iterative process into a scalable, AI-driven system. We provide the tools to advance the fight against genetic disease through precision medicine.
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