Forge: Generative AI Engine

An agentic platform for designing cancer immunotherapies: from automated variant interpretation to in silico therapeutic validation.

Generative AI APIs

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Design Genetic Warhead

Engineer and validate hyper-lethal CRISPR guide RNAs for absolute precision gene annihilation or forced activation.

CAPABILITIES:

  • •De Novo Warhead Design
  • •Kill Probability Prediction (via Zeta Index)
  • •Zero Collateral Damage Analysis (Genome-Wide)

USE CASES:

Oncogene Assassination
Design genetic weapons to permanently execute oncogenes or other disease-driving command nodes.
Forced Gene Activation (CRISPRa)
Engineer payloads to forcibly reactivate dormant tumor suppressor genes.
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Engineer Correction Template

Forge flawless, high-efficiency DNA repair templates for perfect, scarless correction of genetic defects.

CAPABILITIES:

  • •Biologically-Optimized Homology Arms (up to 10kb)
  • •Predictive HDR Success Rate > 85%
  • •Suppression of Indel Formation

USE CASES:

Genetic Defect Reversal
Reverse catastrophic, disease-causing mutations with absolute fidelity.
Strategic Payload Integration
Insert any genetic circuit or therapeutic payload into genomically stable safe harbors.
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Forge Biologic Weapon

Engineer de novo protein weapons (e.g., nanobodies, inhibitors) with overwhelming therapeutic superiority.

CAPABILITIES:

  • •Picomolar Binding Affinity Prediction
  • •Extreme Thermostability Engineering
  • •Immunogenic Signature Erasure

USE CASES:

De Novo Biologics
Design hyper-potent nanobodies or molecular inhibitors to neutralize any biological target.
Enzyme Augmentation
Engineer hyper-efficient enzymes to correct metabolic disorders or degrade toxins.
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Forge Synthetic Genome

Generate entire, biologically coherent genomes from scratch, authoring new blueprints for life.

CAPABILITIES:

  • •Planetary-Scale Generation (up to 10Mb)
  • •Perfect Synteny and Gene Architecture
  • •De Novo Functional Gene Creation

USE CASES:

Synthetic Life Design
Generate complete and functional mitochondrial, prokaryotic, or eukaryotic genomes.
Genetic Blueprint Completion
Complete and perfect partial genetic blueprints with flawless accuracy.
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Forge Genetic Switch

Design hyper-specific genetic "on/off" switches that respond to precise cellular states.

CAPABILITIES:

  • •Tissue-Specific Expression Control
  • •Custom Transcription Factor Logic
  • •Epigenetic State Programming

USE CASES:

Stealth Gene Therapy
Create regulatory elements that only activate a therapeutic gene in the target tissue.
Programmable Genetic Circuits
Engineer genetic logic gates for advanced synthetic biology.

Multi-Modal Generation

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Guide RNA Design

Generate CRISPR guide RNAs with minimal off-targets and maximum on-target efficiency using Evo2's genomic understanding.

92%
On-target efficiency
<0.1
Off-target score
~30s
Design time

KEY FEATURES:

Multi-objective optimizationOff-target minimizationPAM compatibilityMultiplex design
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HDR Repair Templates

Design optimized repair templates with ultra-long homology arms for precise genome editing and therapeutic corrections.

78%
HDR efficiency
4.2kb
Avg arm length
94%
Success rate

KEY FEATURES:

Ultra-long homology arms (4kb+)Mutation correctionInsert optimizationRecombination efficiency
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Therapeutic Proteins

Generate optimized protein sequences for enhanced therapeutic properties, including improved stability, binding affinity, and reduced immunogenicity.

+67%
Binding affinity
+43%
Stability improvement
+89%
Expression yield

KEY FEATURES:

Antibody optimizationEnzyme engineeringStability enhancementImmunogenicity reduction
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Regulatory Elements

Design tissue-specific promoters and enhancers for controlled gene expression with minimal off-target activation.

96%
Specificity
15.3x
Expression fold
<2%
Leakage

KEY FEATURES:

Tissue specificityExpression level tuningInducible systemsMinimal leakage
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Epigenome Engineering

Optimize sequences for enhanced chromatin accessibility and favorable epigenetic landscapes.

+72%
Accessibility
+56%
H3K27ac signal
-84%
Methylation reduction

KEY FEATURES:

Chromatin accessibilityHistone modificationDNA methylation patternsNucleosome positioning

Therapeutic Use Cases

Powered by Evo2 40B-parameter foundation model with 1M-token context window