🏥ONCOLOGY CAPABILITY

Resistance Prediction: Level 3 of CSI Journey

Predict When Chemo Might Stop Working

Once you have CSI score and treatment history, unlock resistance prediction. Post-treatment pathway profiling (validated AUROC 0.714-0.750, n=11) captures tumor evolution and predicts when to retest CSI.

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Level 3 of CSI Journey: KILL CHAIN + SPE

What resistance class is active right now? Monitors 10 resistance classes validated across 680 patients from 6 independent datasets with temporal ctDNA modeling.

Data Required

Post-treatment pathway profiling + resistance markers + ctDNA

Unlocks
  • •10 resistance class detection (BRCA reversion, ABCB1 efflux, SLFN11, lineage plasticity)
  • •6 independent datasets (ARIEL, Patch, Christie, TCGA-OV, Abbott, MSK-SPECTRUM)
  • •Temporal ctDNA resistance modeling (27 paired ARIEL profiles)
RETROSPECTIVE TESTED680 patients, 10 resistance classes, 6 datasets, SLFN11 33.6% detection
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API Endpoints

/predict_gene_essentiality
/predict_chromatin_accessibility
/predict_protein_functionality_change