The Question Nobody Was Answering
"What can I do to help myself during treatment?"
Traditional Approach
Eat healthy. Stay hydrated. Avoid grapefruit.
Our System's Answer
Your carboplatin + BRCA1 = DNA repair stress. NAC helps. Here's when.
Until now, nobody could answer that question.
We just built the first system that can.
The Problem: Germline Variants Cause Severe Drug Toxicity
Like prescribing drugs without knowing if the patient can metabolize them
Germline variants can cause severe drug toxicity. Patients with pharmacogene variants face life-threatening reactions when prescribed certain drugs.
The core challenges:
- Pharmacogene variants affect drug breakdown - Variants in DPYD, TPMT, UGT1A1, and other drug-metabolizing enzymes can cause drugs to accumulate to toxic levels. For example, DPYD variants cause 5-10% mortality risk with 5-FU if not detected.
- Drug MoA overlaps with patient's germline pathway vulnerabilities - When a drug's mechanism of action (like platinum agents damaging DNA) overlaps with a patient's germline pathway vulnerabilities (like BRCA1 mutations affecting DNA repair), the toxicity risk multiplies.
- Need mechanism-based food recommendations - Generic "eat healthy" advice doesn't help. Patients need specific foods that support the exact pathways their drugs stress. For example, NAC (N-acetylcysteine) specifically supports DNA repair pathways stressed by platinum agents.
Until now, there was no system that could: - Screen for pharmacogene variants before prescribing - Compute pathway overlap between drug MoA and patient variants - Recommend pathway-specific mitigating foods with timing and dosage
Until now.
Pharmacogene Variants Undetected
DPYD, TPMT, UGT1A1 variants cause severe toxicity but aren't routinely screened
Pathway Overlap Unknown
Drug MoA overlaps with patient's germline vulnerabilities, multiplying risk
Generic Nutrition Advice
Patients get generic 'eat healthy' instead of pathway-specific foods
Until now.
The Solution: Toxicity-Aware Nutrition
We've built the first system that prevents drug toxicity by identifying germline risks and recommending protective foods.
Screen for Pharmacogene Variants
Test patient's genetics for variants in drug-metabolizing enzymes
Key Metrics
The Patient MOAT (What We Just Built)
Identifies which biological pathways your drug stresses
Knows which foods support those pathways
Knows when to take supplements (during vs. after infusion)
This is the first system that connects
toxicity detection to precision nutrition.
Value Propositions
How Toxicity Risk Assessment helps different audiences
For Clinicians
- Flags pharmacogene variants (DPYD, TPMT, UGT1A1, CYP2D6) that affect drug metabolism.
- Identifies pathway overlap between patient germline variants and drug toxic pathways.
- Recommends pathway-specific foods (NAC, Omega-3, CoQ10) with timing and dosage.
For Researchers
- Transparent pathway-based risk assessment (DNA repair, inflammation, cardiometabolic).
- Mechanism-based food recommendations with LLM-enhanced explanations.
- Conservative approach: Better to flag potential risks than miss them.
How Toxicity Detection Works (Four Steps)
Observed Outcomes
Real capabilities and metrics from our toxicity risk assessment system
Pharmacogene Detection
Identifies variants in DPYD, TPMT, UGT1A1, CYP2D6, and other drug-metabolizing enzymes.
Pathway Overlap Analysis
Computes overlap between patient germline variants and drug MoA toxic pathways.
Mitigating Foods
Recommends pathway-specific foods (NAC, Vitamin D, Omega-3, CoQ10) with timing and dosage.
LLM Explanations
Personalized explanations for why foods mitigate toxicity, with patient-friendly summaries.
Core Capabilities
Deep dive into each capability: technical implementation, scientific foundation, and business value
The Complete Toxicity Assessment Flow
Pharmacogene Screening
Screen 20+ drug-metabolizing enzymes for variants
Pathway Overlap Computation
Map drug MoA to toxic pathways and compute overlap with patient variants
Risk Assessment
Calculate toxicity risk based on pharmacogene variants and pathway overlap
Food Mapping
Map pathway overlap to mitigating foods with timing and dosage
LLM Explanation
Generate personalized explanations for why foods mitigate toxicity
THE MOAT: What No Competitor Has
"What should I eat during carboplatin treatment?"
Generic AI Response
"Eat healthy. Stay hydrated. Avoid grapefruit."
Our System's Response
"You're on carboplatin (DNA repair stress) with BRCA1 (sensitive). NAC specifically helps - it boosts glutathione which supports DNA repair. Take 600mg twice daily AFTER infusion, not during. Here's why this matters for YOU."
Feature Comparison
| Feature | Generic AI | Our System |
|---|---|---|
| Toxicity Detection | None | ✅ DPYD/TPMT/UGT1A1/CYP2D6 screening |
| Drug-Specific Nutrition | Generic | ✅ 'NAC for carboplatin + BRCA1' |
| Timing Guidance | None | ✅ 'Post-chemo, not during' |
| Mechanism Explanation | None | ✅ 'Glutathione supports DNA repair' |
| Germline Awareness | None | ✅ 'Your BRCA1 increases stress' |
That's the difference.
Not generic advice. Precision nutrition for precision oncology.
A Real Patient Story: Ayesha on Carboplatin
Meet Ayesha
Her Question:
"What can I eat to help myself during carboplatin treatment?"
The Complete Solution
Pharmacogene Screening
Screened for DPYD, TPMT, UGT1A1 variants. No high-risk variants detected.
Result: Safe to proceed with carboplatin
Pathway Overlap Analysis
Carboplatin → DNA repair pathway stressed (score: 1.0). BRCA1 germline variant increases DNA repair pathway stress.
Result: DNA repair pathway identified as at-risk
Mitigating Foods Recommendation
NAC (glutathione precursor) specifically helps - supports DNA repair enzymes. Vitamin D and Folate also recommended.
Result: NAC, Vitamin D, Folate recommended
Timing Guidance
Take NAC post-chemo (not during infusion). Continuous Vitamin D supplementation.
Result: Personalized timing provided
Real-World Impact
Before: Isolated recommendations. "Here's a drug." "Here's a trial." "Eat healthy."
After: Complete care plan that adapts when biology adapts.
How This Fits Into Complete Care Plan
Connected Capabilities
Connects toxicity pathways to protective foods
Flags variants before prescribing to prevent toxicity
Maps drug MoA to toxic pathways and recommends pathway-specific foods
Care Plan Integration
Risks/Toxicity
Screens for pharmacogene variants and drug interactions before prescribing
Food Validation
Validates foods with drug and germline context, recommends timing
This capability is part of a complete, adaptive care plan
that anticipates resistance, recommends combinations, and monitors continuously.
From Traditional Challenges to AI-Powered Solutions
Explore how CrisPRO transforms healthcare workflows across different capabilities
Toxicity Risk Assessment Journey
From reactive toxicity management to proactive risk identification
Reactive Toxicity Management
Toxicities discovered only after treatment begins, often too late to prevent serious adverse events
Proactive Risk Identification
AI-powered germline analysis identifies toxicity risks before treatment begins