Design the Undruggable
Validate in Silico
De-risk development with in-silico validation before spending millions on wet lab work. Every design is validated with structural confidence and mechanistic explanations.
Target Discovery
95.7% AUROC validation
Therapeutic Design
70% functional coherence
Structural Validation
95.8% confidence
Transform Drug Development Economics
Every metric validated with real-world performance. De-risk development before wet lab investment with in-silico validation.
Target Validation AUROC
Zero-shot variant impact prediction on ClinVar benchmark
Functional Coherence
Pfam-hit rate for generated therapeutic sequences
Structural Confidence
Average confidence for validated 3D structures
Time to First Hit
vs 18 months traditional approach
Cost Reduction
$2.5M → $3K per target validation
Validation Pass Rate
On all validation benchmarks
Every metric validated with real-world performance. De-risk development before wet lab investment with in-silico validation.
Experience Complete R&D Platform
Click on any R&D capability below to see how CrisPRO.ai transforms therapeutic development with real-time demonstrations and validated results.
Target Discovery & Validation
Zero-shot variant impact prediction with Oracle Engine. Identifies therapeutic targets, synthetic lethal pairs, and gene essentiality with validated accuracy.
Therapeutic Design & Generation
Generative AI with Forge Engine. Designs novel proteins, CRISPR guide RNAs, HDR repair templates, and therapeutic sequences with validated biological function.
Structural Validation & Confirmation
3D structural validation with Boltz Engine. AlphaFold 3 integration confirms structural integrity, binding affinity, and therapeutic mechanism.
IND Package Generation
Automated IND-ready dossier generation with complete audit trails, structural validation, and mechanistic explanations for regulatory submission.
IP Monetization Workflow
Complete IP documentation workflow with design provenance, novelty validation, and patent-ready documentation for therapeutic candidates.
Test R&D Capabilities Live
Click on any R&D capability to see how it transforms therapeutic development with validated performance metrics and real-time demonstrations.
R&D Capability Testing Engine
Target Discovery & Validation
95.7% AUROC
Therapeutic Design & Generation
70% functional coherence
Structural Validation & Confirmation
95.8% confidence
IND Package Generation
Complete dossier
IP Monetization Workflow
Patent-worthy designs
🔬 Experience Our R&D Capabilities
De-risk development with in-silico validation before spending millions on wet lab work. Every design is validated with structural confidence and mechanistic explanations.
Target Discovery & Validation
Zero-Shot Variant Impact
Experience how Target Discovery & Validation works with real-time AI-powered analysis
Powered by the World's First Biological Foundation Models
These are the AI engines that power CrisPRO R&D. Each engine provides validated technical capabilities for therapeutic design and validation.
Oracle: Discriminative AI Engine
Powered by Evo2 40B-parameter model with 1M-token context window
Core Capabilities
Variant Impact Prediction
95.7% ClinVar AUROC
Gene Essentiality Analysis
0.82-0.99 AUROC range
Forge: Generative AI Engine
An agentic platform for designing cancer immunotherapies: from automated variant interpretation to in silico therapeutic validation.
Core Capabilities
Guide RNA Design
Generate CRISPR guide RNAs with minimal off-targets and maximum on-target efficiency using Evo2's genomic understanding.
HDR Repair Templates
Design optimized repair templates with ultra-long homology arms for precise genome editing and therapeutic corrections.
⚡ Boltz: 3D Structural Assessment
3D structural validation and binding affinity prediction with AlphaFold 3 integration
Core Capabilities
3D Structural Validation
AlphaFold 3 integration for complex confidence scoring
Binding Affinity Prediction
Therapeutic-target interaction analysis
🎯 Command Center: Central Nervous System
Workflow orchestration, provenance tracking, and evidence aggregation
Core Capabilities
Pipeline Orchestration
Multi-engine workflow coordination
Provenance Tracking
Complete audit trail from input to therapeutic design
Explore Other Products
See How R&D Teams Use CrisPRO
Discover how different industries leverage CrisPRO to transform their workflows