CRISPRO · KNOWLEDGE BASE
Research
Four collections from the CrisPRO research team. Choose a tab above to focus one lane, or browse previews below.
Blog
Articles and series on AI oncology and precision medicine.
Article
Lung Cancer Brain Metastasis. Here's What We Found — and Why It Matters for a Cure.
Approximately 20–40% of non-small cell lung cancer (NSCLC) patients develop brain metastases — tumors that have broken away from the primary…
ReadEscape Map
EscapeMap — We Built a Cancer Resistance Engine From Public Data Nobody Was Using
A research series on building AI-driven therapeutic intelligence from the graveyard of failed clinical trials.
Readastrazeneca
Building Brain Metastasis Framework Studying Glioblastoma's (GBM) Trial Failures
Every GBM trial failure carries a failure signature — a specific combination of target validity, delivery architecture, patient selection, a…
Read
Manuscripts
Long-form manuscripts and preprints.
- Manuscript
MBD4 deficiency defines a BER-defective state characterized by cytidine-analog synthetic lethality, replication stress-driven ATR checkpoint dependency, and falsification of a transcriptional PARP1-upregulation model for PARP-trapping vulnerability
Read - Manuscript
Mechanism-Based Trial Matching Reveals a 54% Target Alignment Gap in Ovarian Cancer: Quantifying the Precision-Ineligible Majority
Read - Manuscript
Stage-aware CRISPR design for brain metastasis interception: Multi-modal 'in-silico' framework of BBB extravasation and CNS colonization targets
Read
Decks
Slide decks and programmatic posters.
Abstracts
Conference abstracts with citations.
2235
Intercepting metastasis: 8-step CRISPR design via multi-modal foundation models.
F Kiani
OpenAbstract B065: Stage-aware CRISPR design for brain metastasis interception: Multi-modal validation of BBB extravasation and CNS colonization targets
F Kiani, SA Allah
OpenAbstract LB-B013: Eight-Pathway transcriptomic biomarker outperforms PD-L1 for anti-PD-1 response prediction in melanoma
F Kiani, SA Allah
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