Use Case
CLINICAL
INTERMEDIATE
Synthetic Lethality & Essentiality Agent - Module 14
15-30 minutes
CLINICAL
The Synthetic Lethality & Essentiality Agent identifies double-hit vulnerabilities and scores gene essentiality for precision drug targeting. When cancer cells lose one pathway (e.g., HR), they become dependent on backup pathways (e.g., PARP) - we identify these dependencies and target them with precision drugs.
How It Works
1
**Map Broken Pathways** (identify disrupted pathways)
Map Broken Pathways (identify disrupted pathways)
2
**Identify Essential Backups** (synthetic lethality relationships)
Identify Essential Backups (synthetic lethality relationships)
3
**Recommend Drugs** (targeting essential pathways)
Recommend Drugs (targeting essential pathways)
4
**Generate AI Explanations** (3 audiences: clinician/patient/researcher)
Generate AI Explanations (3 audiences: clinician/patient/researcher)
Key Outcomes
Identify synthetic lethality relationships
Score gene essentiality
Recommend precision drugs
Prerequisites
Basic understanding of cancer biology
Familiarity with genetic variants
Ready to Get Started?
Explore the API endpoints used in this use case and start building your own synthetic lethality analysis.