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  • MBD4 deficiency defines a BER-defective state characterized by cytidine-analog synthetic lethality, replication stress-driven ATR checkpoint dependency, and falsification of a transcriptional PARP1-upregulation model for PARP-trapping vulnerability

  • Mechanism-Based Trial Matching Reveals a 54% Target Alignment Gap in Ovarian Cancer: Quantifying the Precision-Ineligible Majority