8D Vector Failure Analysis
Trial Vector
Responder
Non-Responder
Alignment Zone
cosine = 0.9630
Vector Math
cos(θ) = (A·B) / (||A|| ||B||)
TARGET RESPONDER0.9630
ITT DILUTED0.6560
Observed HR0.90
Gate Evaluation
GATE 1: TARGET MATCHRANK #2 (PTEN-INTACT)
PASS
GATE 2: COHORT EXCLUSIONRANK #2 (SAME RANK, 30PT DROP)
PASS
GATE 3: PREDICTIVE EFFICACYΔ +0.307 (3X THRESHOLD)
PASS
VERDICTFAILURE_PREDICTED
PTEN-intact Sig
0.963Rank #2
PTEN-loss Sig
0.656Rank #2
8D Vector Δ
+0.3073/3 Gates
Validation
MAXStrongest Δ
Market Significance
Target Sub-Pop22,000+ Ovarian US / Yr
Annual Savings$150M+ Patient Selection
CrisPRO would have routed PTEN-loss patients to PI3K inhibitors (capivasertib) instead of WEE1 — before the JCO 2023 data confirmed 0% ORR.
System Summary
Database Scored806 TRIALS
Prediction LayerTWO-LAYER AI
StatusFAILURE PREDICTED
Gates3/3 PASS