8D Vector Failure Analysis
Trial Vector
Responder
Non-Responder
Alignment Zone
cosine = 0.9550
Vector Math
cos(θ) = (A·B) / (||A|| ||B||)
TARGET RESPONDER0.9550
ITT DILUTED0.8170
Observed HR0.90
Gate Evaluation
GATE 1: TARGET MATCHRANK #3 (RS-LOW)
PASS
GATE 2: COHORT EXCLUSIONRANK #3 (SAME RANK, 14PT SCORE DROP)
PASS
GATE 3: PREDICTIVE EFFICACYΔ +0.138 (WAS 0.064 IN 7D)
PASS
VERDICTFAILURE_PREDICTED
RS-Low Sig
0.955Rank #3
RS-High Sig
0.817Rank #3
8D Vector Δ
+0.1383/3 Gates
7D → 8D
0.064→0.138RSS axis
Market Significance
Target Sub-Pop22,000+ Ovarian US / Yr
Annual Savings$100M+ RS-Based Selection
NGS panel sufficient to determine RS status. No RNA-seq required. Standard-of-care genomics can drive this enrichment.
System Summary
Database Scored806 TRIALS
Prediction LayerTWO-LAYER AI
StatusFAILURE PREDICTED
Gates3/3 PASS