NCT02264678 Failure: 8D Vector Analysis
Retrospective Failure Mapping // NCT02264678
Computational Vector Space
TRIAL VECTOR
RESPONDER
NON-RESPONDER
TRIAL VECTOR
RESPONDER
THE GAP:
Δ +0.108
ALIGNMENT ZONE
COSINE = 0.8800
Vector Convergence Math
Formula_Resolve:
cos(θ) = (A·B) / (||A|| ||B||)
TARGET RESPONDER0.8800
ITT DILUTED0.7720
DELTA IMPACT+0.108
Failure Interpretation
Post-PARPi maintenance patients have evolved resistance (BRCA reversion, HR restoration). The combination still targets DDR, but the patient biology has moved past the efficacy window.
Trials Scored806
Gates3/3 PASS
VerdictFAILURE_PREDICTED
Validation TierRetroactive (locked pre-analysis)
In Silico Failure Analyzer v1.4.28D VECTOR ENGINE