8D Vector Failure Analysis
Trial Vector
Responder
Non-Responder
Alignment Zone
cosine = 0.8800
Vector Math
cos(θ) = (A·B) / (||A|| ||B||)
TARGET RESPONDER0.8800
ITT DILUTED0.7720
Observed HR0.90
Gate Evaluation
GATE 1: TARGET MATCHRANK #422 (DDR CLUSTER — MANY ATRI+PARPI TRIALS)
PASS
GATE 2: COHORT EXCLUSIONRANK #361
PASS
GATE 3: PREDICTIVE EFFICACYΔ +0.108 (AT THRESHOLD)
PASS
VERDICTFAILURE_PREDICTED
PARPi-naive Sig
0.880Rank #422
Post-PARPi Sig
0.772Rank #361
8D Vector Δ
+0.1083/3 Gates
Validation
AT THRNarrowest Δ
Market Significance
Target Sub-Pop22,000+ HGSOC US / Yr
Annual Savings$100M+ Resistance Detection
Serial monitoring for PARPi resistance (Kill Chain) would flag these patients before futile combination therapy — saving time, toxicity, and cost.
System Summary
Database Scored806 TRIALS
Prediction LayerTWO-LAYER AI
StatusFAILURE PREDICTED
Gates3/3 PASS