NCT04154956 Failure: 8D Vector Analysis
Retrospective Failure Mapping // NCT04154956
Computational Vector Space
TRIAL VECTOR
RESPONDER
NON-RESPONDER
TRIAL VECTOR
RESPONDER
THE GAP:
Δ +0.2418
ALIGNMENT ZONE
COSINE = 0.7241
Vector Convergence Math
Formula_Resolve:
cos(θ) = (A·B) / (||A|| ||B||)
TARGET RESPONDER0.7241
ITT DILUTED0.4823
DELTA IMPACT+0.2418
Failure Interpretation
Enrolled unselected NSCLC with CEACAM5 IHC 2+ at ≥50% cells — a threshold insufficiently selective to enrich for the responding subpopulation.
Trials Scored806
Gates2/3 — Layer 2 failed (enrollment gate)
VerdictFAILURE_PREDICTED
Validation TierProspective prediction (locked pre-readout)
In Silico Failure Analyzer v1.4.28D VECTOR ENGINE