NCT05450692 Failure: 8D Vector Analysis
Retrospective Failure Mapping // NCT05450692
Computational Vector Space
TRIAL VECTOR
RESPONDER
NON-RESPONDER
TRIAL VECTOR
RESPONDER
THE GAP:
Δ +0.3658
ALIGNMENT ZONE
COSINE = 0.9852
Vector Convergence Math
Formula_Resolve:
cos(θ) = (A·B) / (||A|| ||B||)
TARGET RESPONDER0.9852
ITT DILUTED0.6194
DELTA IMPACT+0.3658
Failure Interpretation
Trial enrolled unselected patients, missing the STK11/KEAP1 co-mutation signature required for ATRi success.
Trials Scored2888
Gates3/3 PASS
VerdictFAILURE_PREDICTED
Validation TierTier 2 → Tier 1 (upgraded)
In Silico Failure Analyzer v1.4.28D VECTOR ENGINE