MBD4 deficiency defines a BER-defective state characterized by cytidine-analog synthetic lethality, replication stress-driven ATR checkpoint dependency, and falsification of a transcriptional PARP1-upregulation model for PARP-trapping vulnerability
Stage-aware CRISPR design for brain metastasis interception: Multi-modal 'in-silico' framework of BBB extravasation and CNS colonization targets